On Wednesday, Jerry Lewis announced that this year, he will retire as host of the Muscular Dystrophy Association's annual telethon - a position he has filled for 45 years.
The echo chamber that this news created is a testament to how synonymous his name has become with the event, which MDA representatives said has raised more than $1 billion over the years.
More than that, though, it is a testament to a man who has personified that which guides hundreds of thousands of researchers on a daily basis: hope.
Jerry Lewis may not have ever donned a lab coat, but he helped to raise awareness not just of muscular dystrophy, but of the battle that patients with all diseases fight.
Unfortunately, Jerry Lewis's career as host of the telethon has spanned 45 years because, in the absence of a cure, the research (and investment) must still go on.
Similarly, researchers around the world know that they may retire before finding that breakthrough about which they dream.
But what won't retire with Lewis, or with those anonymous researchers, is their hope.