Bradley T. Hyman, MD PhD
Professor of Neurology
Massachusetts General Hospital/Harvard Medical School
Bradley T. Hyman, M.D., Ph.D., is theJohn B. Penney, Jr. Professor of Neurology at Harvard Medical School and Massachusetts General Hospital where he has a clinical practice in the Memory and Disorder Unit and is the Director of the Massachusetts Alzheimer Disease Research Center.
His clinical career is devoted towards the care of patients with dementia. His research laboratory is pursuing research in Alzheimer’s disease, and other neurodegenerative diseases, with a goal of understanding the neuropathophysiologic and genetic factors that underlie dementia.
Dr. Hyman’s laboratory is developing methods to examine clinical-pathological correlates and biomarkers in AD, as well as animal and cell models to explore the natural history of the diseases. A recent focus has been the use of advanced microscopy methods – including multiphoton microscopy for in vivo imaging of plaques, tangles, and synuclein aggregates, as well as FRET methods to detect protein-protein interactions and protein conformation.
Dr. Hyman received a B.A. in chemistry from Northwestern University and a Ph.D. in Biochemistry and M.D. from the University of Iowa, where he also did residency in neurology and fellowships in Behavioral neurology and neuropathology. He joined the faculty at Harvard Medical School in 1989. Dr. Hyman has received the Potamkin Award, a Metropolitan Life Award, a Brookdale Foundation fellowship, an Alzheimer Association Faculty Scholar Award, an Alzheimer Association Pioneer Award, and a National Institute on Aging Merit Award.
Andrew B. and Gretchen P. Jones Professor and Chairman
Department of Neurology, Washington University School of Medicine
David Holtzman attended the Honors Program in Medical Education at Northwestern University receiving his B.S. (1983) and M.D. (1985). He did medical internship followed by Neurology residency at UCSF from 1985-1989. He then did post-doctoral research training in the lab of William C. Mobley, MD, PhD, at UCSF from 1989-1994. At UCSF, he also established the Memory and Cognitive Disorders Clinic and was an Assistant Professor from 1991-1994. He moved to his own laboratory at Washington University in December of 1994. He was named as the Associate Professor of Neurology in 2001, Professor in November of 2002, and as the Andrew B. and Gretchen P. Jones Professor and head of the Department of Neurology in October 2003. In addition to his laboratory, administrative, and teaching duties, Dr. Holtzman is involved in clinical and research activities at the Washington University Alzheimer's Disease Research Center. His lab’s major contributions have been in ascertaining how apoE influences Abeta metabolism and risk for AD, the influence of synaptic activity and sleep on Abeta metabolism, examining the potential ability of anti-Abeta antibodies to act as therapeutically and diagnostically in AD, and establishing new methods to study protein metabolism in the CNS for both diagnostic and theranostic purposes. Past honors include being the recipient of a Paul Beeson Physician Faculty Scholar Award in Aging Research, the 2003 Potamkin Prize from the American Academy of Neurology for research on Alzheimer's, election to the American Society for Clinical Investigation (2004), receiving a MERIT award from the NIA (2004), a 2006 recipient of the MetLife award on Alzheimer's disease, and election to the Institute of Medicine of the National Academy of Sciences in 2008.