Not long ago HIV was an acute, fatal illness. Today, thanks in part to innovative medicines, the U.S. death rate for HIV/AIDS has fallen nearly 85 percent since its peak, and is now considered by many to be a manageable chronic disease. Therapeutic advances have also transformed treatment of rheumatoid arthritis. Medicines used to be limited to treating the symptoms of the disease. Now medicines can target the underlying sources of inflammation, halting progression of the disease. These advances improve the lives of patients and can often help avoid hospital visits, surgeries and long-term care.